“Precision Against Gram-Negatives — Carbapenem-Sparing & Allergy-Safe”.

Aztam is the world’s first and only clinically approved monobactam antibiotic. It delivers potent bactericidal activity exclusively against aerobic Gram-negative bacteria (including Pseudomonas aeruginosa, Enterobacterales and NDM producers) while remaining safe in penicillin/cephalosporin-allergic patients.

Indications:

Urinary tract infections (including pyelonephritis), lower respiratory tract infections, septicemia, skin & soft-tissue infections, intra-abdominal infections, gynecologic infections, febrile neutropenia (in combination), and bacterial meningitis caused by susceptible Gram- negative organisms.

Pharmaceutical Form:

Sterile powder in vial: 1 g

Reconstitution:

Shake well until fully dissolved.

IM (use 1% Lidocaine – never give IV):

• IM: Add at least 3 mL Sterile Water for Injection or 0.9% Sodium Chloride per 1 g.
• IV Injection: Reconstitute 1 g with 6–10 mL Sterile Water for Injection.
• IV Infusion: Dilute each 1 g in at least 50 mL of 0.9% Sodium Chloride or 5% Glucose (final concentration ≤20 mg/mL); infuse over 20–60 minutes.

Dosage:

Adults

• Moderate infections / UTI / SSTI: 1 g every 12 hours
• Severe infections: 1–2 g every 8–12 hours
• Life-threatening infections: 2 g every 6–8 hours
• Maximum: 8 g/day
Children (1 month–16 years):
• Mild/moderate: 30 mg/kg every 8–12 hours
• Severe (e.g. sepsis, cystic fibrosis): 30–50 mg/kg every 6–8 hours (up to 120–200 mg/kg/day)

Adjust dose in renal impairment. Preferred IV route for doses >1 g or severe infections.